Article
Rates of evolutionary change in viruses: patterns and determinants.
Nature reviews. Genetics - 1 Apr 2008
Duffy Siobain, Shackelton Laura A, Holmes Edward C
Abstract excerpt
Understanding the factors that determine the rate at which genomes generate and fix mutations provides important insights into key evolutionary mechanisms. We review our current knowledge of the rates of mutation and substitution, as well as their determinants, in RNA viruses, DNA viruses and retroviruses. We show that the high rate of nucleotide substitution in RNA viruses is matched by some DNA viruses,...
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