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Article

rAAV-Mediated Tumorigenesis: Still Unresolved After an AAV Assault

1 Nov 2012

Abstract excerpt

The risk of oncogenesis mediated by vector-induced insertional mutagenesis during therapeutic gene transfer has received much attention in recent years. Any nucleic acid, regardless of how it is delivered, can cause insertional mutagenesis if it integrates into the genome. The two parameters that define this risk are integration site preference and frequency of integration. Recombinant adeno-associated viral...

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PMID: 23131853
DOI: 10.1038/mt.2012.220

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