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Article

Trichostatin A modulates the macrophage phenotype by enhancing autophagy to reduce inflammation during polymicrobial sepsis.

International immunopharmacology - 1 Dec 2019

Cui Shu-Nan, Chen Zhao-Yuan, Yang Xiao-Bo, Chen Lin, Yang Yi-Yi, Pan Shang-Wen, Wang Ya-Xin, Xu Ji-Qian, Zhou Ting, Xiao Hai-Rong, Qin Lu, Yuan Shi-Ying, Shang You

Abstract excerpt

Sepsis is a syndrome of life-threatening organ dysfunction caused by dysregulated host responses to infection. Macrophage polarization is a key process involved in the pathogenesis of sepsis. Recent evidence has demonstrated that autophagy participates in the regulation of macrophage polarization in different phases of inflammation. Here, we investigated whether trichostatin A (TSA), a histone deacetylase (HDAC)...

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PMID: 31677992
DOI: 10.1016/j.intimp.2019.105973

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