Article
MicroRNA-223 modulates the IL-4-medicated macrophage M2-type polarization to control the progress of sepsis.
International immunopharmacology - 1 Jul 2021
Wang Xiaoya, Zhang Hai, Guo Rui, Li Xiaomin, Liu Haixin, Wang Zhenyu, Du Qian, Tong Dewen, Huang Yong
Abstract excerpt
MicroRNAs play a variety of roles in the progress of inflammation. Herein, we investigated the roles of miR-223 in governing macrophage polarization balance in the progress of sepsis. We firstly observed that miR-223 was down-regulated at the early phase and up-regulated at the late phase of sepsis in macrophages; the levels of miR-223 were positively correlated to the ratio of M2 macrophages during sepsis. In...
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