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Article

Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13.

Biochemical and biophysical research communications - 15 Jan 2020

Cariulo Cristina, Verani Margherita, Martufi Paola, Ingenito Raffaele, Finotto Marco, Deguire Sean M, Lavery Daniel J, Toledo-Sherman Leticia, Lee Ramee, Doherty Elizabeth M, Vogt Thomas F, Dominguez Celia, Lashuel Hilal A, Petricca Lara, Caricasole Andrea

Abstract excerpt

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion of a CAG triplet repeat (encoding for a polyglutamine tract) within the first exon of the huntingtin gene. Expression of the mutant huntingtin (mHTT) protein can result in the production of N-terminal fragments with a robust propensity to form oligomers and aggregates, which may be causally associated with HD pathology....

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Identifiers

PMID: 31677786
DOI: 10.1016/j.bbrc.2019.09.097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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