Article
Mutations of key substrate binding residues of leishmanial peptidase T alter its functional and structural dynamics.
Biochimica et biophysica acta. General subjects - 1 Jan 2020
Bhat Saleem Yousuf, Qureshi Insaf Ahmed
Abstract excerpt
BACKGROUND: M20 aminopeptidases, such as Peptidase T (PepT), are implicated in the hydrolysis of oligopeptides during the terminal stages of protein degradation pathway to maintain turnover. Therefore, specific inhibition of PepT bores well for the development of novel next-generation antileishmanials. This work describes the metal dependence, substrate preferences and inhibition of PepT, and demonstrates in...
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