Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural comparison of human and Plasmodium proteasome β5 subunits: informing selective inhibitor design for anti-malaria agents

21 Jan 2025

Abstract excerpt

BACKGROUND: The Plasmodium proteasome emerges as a promising target for anti-malarial drug development due to its potential activity against multiple life cycle stages. METHODS: In this investigation, a comparative analysis was conducted on the structural features of the β5 subunit in the 20S proteasomes of both Plasmodium and humans. RESULTS: The findings underscore the structural diversity inherent in both...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Malaria Research and Control
Share to Ubiquitin and proteasome pathways
Share to vaccines and immunoinformatics approaches

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39838389
DOI: 10.1186/s12936-025-05259-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural comparison of human and Plasmodium proteasome β5 subunits: informing selective inhibitor design for anti-malaria agentsPMID 39838389Read ↗

Targeting the Plasmodium Ubiquitin/Proteasome System with Anti- Malarial Compounds: Promises for the FutureSemantic proximity Read ↗

Structure-Based Design of β1i or β5i Specific Inhibitors of Human ImmunoproteasomesSemantic proximity Read ↗

Evaluating Antimalarial Proteasome Inhibitors for Efficacy in Babesia Blood Stage CulturesSemantic proximity Read ↗

Ubiquitin Proteasome System as a Potential Drug Target for MalariaSemantic proximity Read ↗

Mammalian deubiquitinating enzyme inhibitors display <i>in vitro</i> and <i>in vivo</i> activity against malaria parasites and potentiate artemisinin actionSemantic proximity Read ↗

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibitionSemantic proximity Read ↗

Mammalian proteasome subtypes: Their diversity in structure and function.Semantic proximity Read ↗

Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan ParasitesSemantic proximity Read ↗

Structural basis of human 20S proteasome biogenesisSemantic proximity Read ↗

Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT)Semantic proximity Read ↗

Mutations of key substrate binding residues of leishmanial peptidase T alter its functional and structural dynamics.Semantic proximity Read ↗

Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone InhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.