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Peptide Deformylase: A New Target in Antibacterial, Antimalarial and Anticancer Drug Discovery

8 Dec 2014

Abstract excerpt

Peptide deformylase (PDF) is a class of metalloenzyme responsible for catalyzing the removal of the N-formyl group from N-terminal methionine following translation. PDF inhibitors are moving into new phase of drug development. Initially, PDF was considered as an important target in antibacterial drug discovery; however genome database searches have revealed PDF-like sequences in parasites (P. falciparum) and...

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PMID: 25174923
DOI: 10.2174/0929867321666140826115734

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