Article
Mutations in ASH1L confer susceptibility to Tourette syndrome.
Molecular psychiatry - 1 Feb 2020
Liu Shiguo, Tian Miaomiao, He Fan, Li Jiani, Xie Hong, Liu Wenmiao, Zhang Yeting, Zhang Ru, Yi Mingji, Che Fengyuan, Ma Xu, Zheng Yi, Deng Hao, Wang Guiju, Chen Lang, Sun Xue, Xu Yinglei, Wang Jingli, Zang Yucui, Han Mengmeng, Wang Xiuhai, Guan Hongzai, Ge Yinlin, Wu Chunmei, Wang Haiyan, Liang Hui, Li Hui, Ran Ni, Yang Zhaochuan, Huang Huanhuan, Wei Yanzhao, Zheng Xueping, Sun Xiangrong, Feng Xueying, Zheng Lanlan, Zhu Tao, Luo Wenhan, Chen Qinan, Yan Yuze, Huang Zuzhou, Jing Zhongcui, Guo Yixia, Zhang Xuzhan, Schaaf Christian P, Xing Jinchuan, Wang Chuanyue, Yu Fuli, Guan Ji-Song
Abstract excerpt
Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder characterized by repetitive motor movements and vocal tics. The clinical manifestations of TS are complex and often overlap with other neuropsychiatric disorders. TS is highly heritable; however, the underlying genetic basis and molecular and neuronal mechanisms of TS remain largely unknown. We performed whole-exome sequencing of a hundred...
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