Article
Identification of candidate genes involved in the etiology of sporadic Tourette syndrome by exome sequencing.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Oct 2017
Eriguchi Yosuke, Kuwabara Hitoshi, Inai Aya, Kawakubo Yuki, Nishimura Fumichika, Kakiuchi Chihiro, Tochigi Mamoru, Ohashi Jun, Aoki Naoto, Kato Kayoko, Ishiura Hiroyuki, Mitsui Jun, Tsuji Shoji, Doi Koichiro, Yoshimura Jun, Morishita Shinichi, Shimada Takafumi, Furukawa Masaomi, Umekage Tadashi, Sasaki Tsukasa, Kasai Kiyoto, KanoMD PhD Yukiko
Abstract excerpt
Tourette Syndrome (TS) is a neurodevelopmental disorder characterized by chronic motor and vocal tics. Although there is a large genetic contribution, the genetic architecture of TS remains unclear. Exome sequencing has successfully revealed the contribution of de novo mutations in sporadic cases with neuropsychiatric disorders such as autism and schizophrenia. Here, using exome sequencing, we investigated de...
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