Article

Distinct patterns of <i>de novo</i> coding variants contribute to Tourette Syndrome etiology

2025-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Tourette syndrome (TS) is a highly heritable childhood-onset neuropsychiatric disorder characterized by persistent motor and vocal tics. While both common and rare variants contribute to TS susceptibility, the role of rare de novo mutations (DNMs) remains incompletely characterized. Here, we report findings from the largest TS whole-exome sequencing study to date, analyzing 1,466 TS trios along...

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Literature Corpus work: f5660313-6d0b-5494-b5da-885efe466b4d
DOI: 10.1101/2025.11.04.686570

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