Article
Structural organization of the intermediate and light chain complex of Chlamydomonas ciliary I1 dynein.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2021
Fu Gang, Scarbrough Chasity, Song Kangkang, Phan Nhan, Wirschell Maureen, Nicastro Daniela
Abstract excerpt
Axonemal I1 dynein (dynein f) is the largest inner dynein arm in cilia and a key regulator of ciliary beating. It consists of two dynein heavy chains, and an intermediate chain/light chain (ICLC) complex. However, the structural organization of the nine ICLC subunits remains largely unknown. Here, we used biochemical and genetic approaches, and cryo-electron tomography imaging in Chlamydomonas to dissect the...
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