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Lack of Sharing of Spam1 (Ph-20) among Mouse Spermatids and Transmission Ratio Distortion1

1 Jun 2001

Abstract excerpt

Gametic equality is thought to exist, despite haploid gene action in mammalian spermiogenesis, because of product sharing via the intercellular bridges of conjoined spermatids. However, mice carrying different t-alleles have been known to produce functionally different sperm, leading to transmission ratio distortion (TRD), whose mechanism is unknown. The reduced Spam1 mRNA levels, previously shown to be...

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PMID: 11369602
DOI: 10.1095/biolreprod64.6.1730

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