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Functional Characterization of Double-knockout Mouse Sperm Lacking SPAM1 and ACR or SPAM1 and PRSS21 in Fertilization

1 Jan 2012

Abstract excerpt

Mammalian fertilization requires sperm to penetrate the cumulus to reach the oocyte. Although sperm hyaluronidase has long been believed to participate in the penetration process, our previous works revealed that neither of two sperm hyaluronidases, SPAM1 and HYAL5, are essential for fertilization. In this study, we have produced double-knockout mice lacking SPAM1 and either one of two sperm serine proteases, ACR...

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Identifiers

PMID: 22362218
DOI: 10.1262/jrd.2011-006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertility†Semantic proximity Read ↗

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