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Article

Spam1-associated transmission ratio distortion in mice: elucidating the mechanism.

Reproductive biology and endocrinology : RB&E - 10 Aug 2005

Martin-DeLeon Patricia A, Zhang Hong, Morales Carlos R, Zhao Yutong, Rulon Michelle, Barnoski Barry L, Chen Hong, Galileo Deni S

Abstract excerpt

BACKGROUND: While transmission ratio distortion, TRD, (a deviation from Mendelian ratio) is extensive in humans and well-documented in mice, the underlying mechanisms are unknown. Our earlier studies on carriers of spontaneous mutations of mouse Sperm Adhesion Molecule 1 (Spam1) suggested that TRD results from biochemically different sperm, due to a lack of transcript sharing through the intercellular cytoplasmic...

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Source

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Identifiers

PMID: 16092963
DOI: 10.1186/1477-7827-3-32
PMCID: PMC1201170

Genes

TRD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Spam1-associated transmission ratio distortion in mice: elucidating the mechanism.PMID 16092963Read ↗

Lack of Sharing of Spam1 (Ph-20) among Mouse Spermatids and Transmission Ratio Distortion1Semantic proximity Read ↗

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Epididymal SPAM1 Is a Marker for Sperm Maturation in the Mouse1Semantic proximity Read ↗

Spam1 (PH-20) mutations and sperm dysfunction in mice with the Rb(6.16) or Rb(6.15) translocation.Semantic proximity Read ↗

SPAM1/HYAL5 double deficiency in male mice leads to severe male subfertility caused by a cumulus‐oocyte complex penetration defectSemantic proximity Read ↗

Functional Characterization of Double-knockout Mouse Sperm Lacking SPAM1 and ACR or SPAM1 and PRSS21 in FertilizationSemantic proximity Read ↗

Abnormal gene expression in regular and aggregated somatic cell nuclear transfer placentasSemantic proximity Read ↗

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