Article
Parkinson's Disease: Glucocerebrosidase 1 Mutation Severity Is Associated with CSF Alpha-Synuclein Profiles.
Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2020
Lerche Stefanie, Wurster Isabel, Roeben Benjamin, Zimmermann Milan, Riebenbauer Benjamin, Deuschle Christian, Hauser Ann-Kathrin, Schulte Claudia, Berg Daniela, Maetzler Walter, Waniek Katharina, Lachmann Ingolf, Liepelt-Scarfone Inga, Gasser Thomas, Brockmann Kathrin
Abstract excerpt
BACKGROUND: Mutations in the gene glucocerebrosidase (GBA1) are specifically associated with alpha-synucleinopathies, namely, Parkinson's disease (PD) and dementia with Lewy bodies. As disease-modifying treatment options such as alpha-synuclein lowering compounds are under way, patient stratification according to alpha-synuclein-specific enrichment strategies, possibly reflected by cerebrospinal fluid (CSF)...
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