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Article

Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues

29 Oct 2019

Abstract excerpt

BACKGROUND: Genomic imprinting is an epigenetic phenomenon that allows a subset of genes to be expressed mono-allelically based on the parent of origin and is typically regulated by differential DNA methylation inherited from gametes. Imprinting is pervasive in murine extra-embryonic lineages, and uniquely, the imprinting of several genes has been found to be conferred non-canonically through maternally inherited...

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PMID: 31665063
DOI: 10.1186/s13059-019-1833-x

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