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Roles of endogenous retroviral elements in the establishment and maintenance of imprinted gene expression

5 Mar 2024

Abstract excerpt

DNA methylation (DNAme) has long been recognized as a host defense mechanism, both in the restriction modification systems of prokaryotes as well as in the transcriptional silencing of repetitive elements in mammals. When DNAme was shown to be implicated as a key epigenetic mechanism in the regulation of imprinted genes in mammals, a parallel with host defense mechanisms was drawn, suggesting perhaps a common...

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PMID: 38505259
DOI: 10.3389/fcell.2024.1369751

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