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Article

H3K9 Methyltransferase EHMT2/G9a Controls ERVK-Driven Noncanonical Imprinted Genes

1 Aug 2021

Abstract excerpt

Aim: Paternal allele-specific expression of noncanonical imprinted genes in the extraembryonic lineages depends on an H3K27me3-based imprint in the oocyte, which is not a lasting mark. We hypothesized that EHMT2, the main euchromatic H3K9 dimethyltransferase, also has a role in controlling noncanonical imprinting. Methods: We carried out allele-specific total RNA-seq analysis in the ectoplacental cone of...

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Share to Epigenetics and DNA Methylation
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PMID: 34519223
DOI: 10.2217/epi-2021-0168

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