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Article

Targeted multiomics in childhood-onset SLE reveal distinct biological phenotypes associated with disease activity: results from an explorative study.

Lupus science & medicine - 1 Apr 2023

Wahadat Mohamed Javad, van Tilburg Sander J, Mueller Yvonne M, de Wit Harm, Van Helden-Meeuwsen Cornelia G, Langerak Anton W, Gruijters Marike J, Mubarak Amani, Verkaaik Marleen, Katsikis Peter D, Versnel Marjan A, Kamphuis Sylvia

Abstract excerpt

OBJECTIVE: To combine targeted transcriptomic and proteomic data in an unsupervised hierarchical clustering method to stratify patients with childhood-onset SLE (cSLE) into similar biological phenotypes, and study the immunological cellular landscape that characterises the clusters. METHODS: Targeted whole blood gene expression and serum cytokines were determined in patients with cSLE, preselected on disease...

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Identifiers

PMID: 37012057
DOI: 10.1136/lupus-2022-000799
PMCID: PMC10083882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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