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Article

Cytosolic phospholipase A2 is a key regulator of blood-brain barrier function in epilepsy.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2019

Hartz Anika M S, Rempe Ralf G, Soldner Emma L B, Pekcec Anton, Schlichtiger Juli, Kryscio Richard, Bauer Bjoern

Abstract excerpt

Blood-brain barrier dysfunction in epilepsy contributes to seizures and resistance to antiseizure drugs. Reports show that seizures increase brain glutamate levels, leading to barrier dysfunction. One component of barrier dysfunction is overexpression of the drug efflux transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). Based on our previous studies, we hypothesized that glutamate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31661303
DOI: 10.1096/fj.201901369RR
PMCID: PMC6894050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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