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Article

Mechanisms of drug resistance in status epilepticus

30 Oct 2007

Abstract excerpt

Refractory status epilepticus (RSE) is a major medical emergency, defined as severe form of SE that does not respond to first (benzodiazepines) and second (phenytoin, phenobarbital) treatment efforts with antiepileptic drugs (AEDs). Understanding the mechanisms of RSE is important to prevent or reverse its development. Based on both clinical experience and data from rat models of SE, seizures that last more than...

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PMID: 18330007
DOI: 10.1111/j.1528-1167.2007.01357.x

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