Article
Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms.
Antimicrobial agents and chemotherapy - 20 Dec 2019
Jones Adriana K, Caughlan Ruth E, Woods Angela L, Uehara Kyoko, Xie Lili, Barnes S Whitney, Walker John R, Thompson Katherine V, Ranjitkar Srijan, Lee Patrick S, Dean Charles R
Abstract excerpt
Upregulated expression of efflux pumps, lpxC target mutations, LpxC protein overexpression, and mutations in fabG were previously shown to mediate single-step resistance to the LpxC inhibitor CHIR-090 in P. aeruginosa Single-step selection experiments using three recently described LpxC inhibitors (compounds 2, 3, and 4) and mutant characterization showed that these mechanisms affect susceptibility to additional...
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