A Common Tag Nucleotide Variant in MMP7 Promoter Increases Risk for Hypertension via Enhanced Interactions With CREB (Cyclic AMP Response Element-Binding Protein) Transcription Factor.

doi:10.1161/HYPERTENSIONAHA.119.12960

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Article

A Common Tag Nucleotide Variant in MMP7 Promoter Increases Risk for Hypertension via Enhanced Interactions With CREB (Cyclic AMP Response Element-Binding Protein) Transcription Factor.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2019

Subramanian Lakshmi, Maghajothi Sakthisree, Singh Mrityunjay, Kesh Kousik, Kalyani Ananthamohan, Sharma Saurabh, Khullar Madhu, Victor Suma M, Swarnakar Snehasikta, Asthana Shailendra, Mullasari Ajit S, Mahapatra Nitish R

Abstract excerpt

MMP (matrix metalloproteinase)-7-a potent extracellular matrix degrading enzyme-is emerging as a new regulator of cardiovascular diseases. However, potential contributions of MMP7 genetic variations to hypertension remain unknown. In this study, we probed for the association of a tag single-nucleotide polymorphism in the MMP7 promoter (-181A/G; rs11568818) with hypertension in an urban South Indian population...

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PMID: 31656093
DOI: 10.1161/HYPERTENSIONAHA.119.12960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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