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Article

A Single Nucleotide Polymorphism near the CYP17A1 Gene Is Associated with Left Ventricular Mass in Hypertensive Patients under Pharmacotherapy.

International journal of molecular sciences - 30 Jul 2015

Huber Matthias, Lezius Susanne, Reibis Rona, Treszl Andras, Kujawinska Dorota, Jakob Stefanie, Wegscheider Karl, Völler Heinz, Kreutz Reinhold

Abstract excerpt

Cytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. They are involved in blood pressure (BP) regulation and in the pathogenesis of left ventricular hypertrophy. Therefore, altered function of CYP17A1 due to genetic variants may influence BP and left ventricular mass. Notably, genome wide association studies supported the role of this enzyme in BP control. Against this...

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Identifiers

PMID: 26263970
DOI: 10.3390/ijms160817456
PMCID: PMC4581202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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