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Dupuytren's contracture-associated SNPs increase SFRP4 expression in non-immune cells including fibroblasts to enhance inflammation development.

International immunology - 7 Jul 2023

Kida Hiroaki, Jiang Jing-Jing, Matsui Yuichiro, Takahashi Ikuko, Hasebe Rie, Kawamura Daisuke, Endo Takeshi, Shibayama Hiroki, Kondo Makoto, Nishio Yasuhiko, Nishida Kinya, Matsuno Yoshihiro, Oikawa Tsukasa, Kubota Shimpei I, Hojyo Shintaro, Iwasaki Norimasa, Hashimoto Shigeru, Tanaka Yuki, Murakami Masaaki

Abstract excerpt

Dupuytren's contracture (DC) is an inflammatory fibrosis characterized by fibroproliferative disorders of the palmar aponeurosis, for which there is no effective treatment. Although several genome-wide association studies have identified risk alleles associated with DC, the functional linkage between these alleles and the pathogenesis remains elusive. We here focused on two single nucleotide polymorphisms (SNPs)...

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PMID: 36719100
DOI: 10.1093/intimm/dxad004

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