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Article

The evaluation of VEGF and HIF-1α gene polymorphisms and multiple sclerosis susceptibility.

The journal of gene medicine - 1 Dec 2019

Saravani Mohsen, Rokni Mohsen, Mehrbani Mehrzad, Amirkhosravi Arian, Faramarz Sanaz, Fatemi Iman, Esmaeili Tarzi Mojdeh, Nematollahi Mohammad Hadi

Abstract excerpt

BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease that leads to myelin sheath destruction. Hypoxia-inducible factor 1 (HIF-1) has several roles in cells, such as inducing inflammation and angiogenesis. Recently, several lines of evidence have indicated the role of the hypoxia response and the HIF-1 signaling pathway in an autoimmune disease such as MS. The present study aimed to evaluate the effects of...

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Identifiers

PMID: 31652374
DOI: 10.1002/jgm.3132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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