Relationship of single nucleotide polymorphisms and haplotype interaction of mitochondrial unfolded protein response pathway genes with head and neck cancer.

doi:10.2217/fon-2019-0365

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Article

Relationship of single nucleotide polymorphisms and haplotype interaction of mitochondrial unfolded protein response pathway genes with head and neck cancer.

Future oncology (London, England) - 1 Nov 2019

Ahmed Malik Waqar, Mahjabeen Ishrat, Gul Shazma, Khursheed Anum, Mehmood Azhar, Kayani Mahmood Akhtar

Abstract excerpt

Aim: In this study, we evaluated the effect of selected polymorphisms of mitochondrial unfolded protein response (UPRmt) pathway in 500 head and neck cancer (HNC) patients and 500 healthy controls from Pakistan. Materials & methods: The experiments were conducted using tetra-ARMS PCR followed by DNA sequencing. Results: Multivariate analysis showed that AA genotype of rs3782116 showed fivefold, GG genotype of...

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PMID: 31651195
DOI: 10.2217/fon-2019-0365

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