Article
7T Proton Magnetic Resonance Spectroscopy of Gamma-Aminobutyric Acid, Glutamate, and Glutamine Reveals Altered Concentrations in Patients With Schizophrenia and Healthy Siblings.
Biological psychiatry - 15 Mar 2017
Thakkar Katharine N, Rösler Lara, Wijnen Jannie P, Boer Vincent O, Klomp Dennis W J, Cahn Wiepke, Kahn René S, Neggers Sebastiaan F W
Abstract excerpt
BACKGROUND: The N-methyl-D-aspartate receptor hypofunction model of schizophrenia predicts dysfunction in both glutamatergic and gamma-aminobutyric acidergic (GABAergic) transmission. We addressed this hypothesis by measuring GABA, glutamate, glutamine, and the sum of glutamine plus glutamate concentrations in vivo in patients with schizophrenia using proton magnetic resonance spectroscopy at 7T, which allows...
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