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Article

Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio.

Nucleic acids research - 10 Jan 2020

Schmidt Tobias T, Sharma Sushma, Reyes Gloria X, Kolodziejczak Anna, Wagner Tina, Luke Brian, Hofer Anders, Chabes Andrei, Hombauer Hans

Abstract excerpt

The accumulation of mutations is frequently associated with alterations in gene function leading to the onset of diseases, including cancer. Aiming to find novel genes that contribute to the stability of the genome, we screened the Saccharomyces cerevisiae deletion collection for increased mutator phenotypes. Among the identified genes, we discovered MET7, which encodes folylpolyglutamate synthetase (FPGS), an...

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PMID: 31647103
DOI: 10.1093/nar/gkz1006
PMCID: PMC7145683

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Source receipt: pubmed, retrieved 7 Sept 2026.

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