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α-Synuclein Accumulation in SH-SY5Y Cell Impairs Autophagy in Microglia by Exosomes Overloading MiR-19a-3p

24 Oct 2019

Abstract excerpt

Aims: To reveal whether miRNAs in exosomes from α-synuclein transgenic SH-SY5Y cells are able to regulate autophagy in recipient microglia. Materials & methods: Microarray analysis and experimental verification were adopted to assess the significance of autophagy-associated miRNAs in exosomes from neuronal model of α-synucleinopathies. Results: We found that miR-19a-3p increased remarkably in the exosomes from...

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PMID: 31646884
DOI: 10.2217/epi-2019-0222

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