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Article

Regular Exercise Prolongs Survival in a Type 2 Spinal Muscular Atrophy Model Mouse

17 Aug 2005

Abstract excerpt

Several studies indicate that physical exercise is likely to be neuroprotective, even in the case of neuromuscular disease. In the present work, we evaluated the efficiency of running-based training on type 2 spinal muscular atrophy (SMA)-like mice. The model used in this study is an SMN (survival motor neuron)-null mouse carrying one copy of a transgene of human SMN2. The running-induced benefits sustained the...

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PMID: 16107648
DOI: 10.1523/jneurosci.1245-05.2005

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