Article
Advances in the understanding of skeletal muscle weakness in murine models of diseases affecting nerve-evoked muscle activity, motor neurons, synapses and myofibers.
Neuromuscular disorders : NMD - 1 Nov 2014
Ferry Arnaud, Joanne Pierre, Hadj-Said Wahiba, Vignaud Alban, Lilienbaum Alain, Hourdé Christophe, Medja Fadia, Noirez Philippe, Charbonnier Frederic, Chatonnet Arnaud, Chevessier Frederic, Nicole Sophie, Agbulut Onnik, Butler-Browne Gillian
Abstract excerpt
Disease processes and trauma affecting nerve-evoked muscle activity, motor neurons, synapses and myofibers cause different levels of muscle weakness, i.e., reduced maximal force production in response to voluntary activation or nerve stimulation. However, the mechanisms of muscle weakness are not well known. Using murine models of amyotrophic lateral sclerosis (SOD1(G93A) transgenic mice), congenital myasthenic...
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