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Increasing MuSK Activity Delays Denervation and Improves Motor Function in ALS Mice

30 Aug 2012

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating disease that progresses from detachment of motor nerve terminals to complete muscle paralysis and lethal respiratory failure within 5 years of diagnosis. Genetic studies have linked mutations in several genes to ALS, and mice bearing mutations in SOD1 recapitulate hallmark features of the disease. We investigated whether disease symptoms can be ameliorated by...

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PMID: 22939980
DOI: 10.1016/j.celrep.2012.08.004

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