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Article

Effect of CYP3A5*3 genetic variant on the metabolism of direct-acting antivirals in vitro: a different effect on asunaprevir versus daclatasvir and beclabuvir.

Journal of human genetics - 1 Jan 2020

Matsumoto Jun, San Su Nwe, Fujiyoshi Masachika, Kawauchi Ayano, Chiba Natsumi, Tagai Ran, Sanbe Ryoko, Yanaka Shiho, Sakaue Hiroaki, Kato Yoshinori, Nakamura Hiroyoshi, Yamada Harumi, Ariyoshi Noritaka

Abstract excerpt

Direct-acting antivirals, asunaprevir (ASV), daclatasvir (DCV), and beclabuvir (BCV) are known to be mainly metabolized by CYP3A enzymes; however, the differences in the detailed metabolic activities of CYP3A4 and CYP3A5 on these drugs are not well clarified. The aim of the present study was to elucidate the relative contributions of CYP3A4 and CYP3A5 to the metabolism of ASV, DCV, and BCV, as well as the effect...

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PMID: 31645655
DOI: 10.1038/s10038-019-0685-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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