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Article

Cytochrome P450 3A5 plays a prominent role in the oxidative metabolism of the anti-human immunodeficiency virus drug maraviroc.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2012

Lu Yanhui, Hendrix Craig W, Bumpus Namandjé N

Abstract excerpt

Maraviroc is an anti-human immunodeficiency virus drug that acts by blocking viral entry into target cells. With use of ultra-performance liquid chromatography-mass spectrometry several monooxygenated, dioxygenated, and glucuronidated metabolites of maraviroc were identified both in vitro and in vivo. Characterization of the enzymes involved in the production of these metabolites determined that cytochrome P450...

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Identifiers

PMID: 22923690
DOI: 10.1124/dmd.112.048298
PMCID: PMC3500548

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