Article
Genetics of Circulating Resistin Level, a Biomarker for Cardiovascular Diseases, Is Informed by Mendelian Randomization and the Unique Characteristics of African Genomes.
Circulation. Genomic and precision medicine - 1 Oct 2020
Meeks Karlijn A C, Doumatey Ayo P, Bentley Amy R, Gouveia Mateus H, Chen Guanjie, Zhou Jie, Lei Lin, Adeyemo Adebowale A, Rotimi Charles N
Abstract excerpt
BACKGROUND: Resistin, a protein linked with inflammation and cardiometabolic diseases, is one of few proteins for which genome-wide association studies consistently report variants within and near the coding gene (RETN). Here, we took advantage of the reduced linkage disequilibrium in African populations to infer genetic causality for circulating resistin levels by performing genome-wide association studies,...
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