Article
Network-Based Functional Prediction Augments Genetic Association To Predict Candidate Genes for Histamine Hypersensitivity in Mice.
G3 (Bethesda, Md.) - 3 Dec 2019
Tyler Anna L, Raza Abbas, Krementsov Dimitry N, Case Laure K, Huang Rui, Ma Runlin Z, Blankenhorn Elizabeth P, Teuscher Cory, Mahoney J Matthew
Abstract excerpt
Genetic mapping is a primary tool of genetics in model organisms; however, many quantitative trait loci (QTL) contain tens or hundreds of positional candidate genes. Prioritizing these genes for validation is often ad hoc and biased by previous findings. Here we present a technique for prioritizing positional candidates based on computationally inferred gene function. Our method uses machine learning with...
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