Article
Prioritizing causal disease genes using unbiased genomic features.
Genome biology - 3 Dec 2014
Deo Rahul C, Musso Gabriel, Tasan Murat, Tang Paul, Poon Annie, Yuan Christiana, Felix Janine F, Vasan Ramachandran S, Beroukhim Rameen, De Marco Teresa, Kwok Pui-Yan, MacRae Calum A, Roth Frederick P
Abstract excerpt
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in the developed world. Human genetic studies, including genome-wide sequencing and SNP-array approaches, promise to reveal disease genes and mechanisms representing new therapeutic targets. In practice, however, identification of the actual genes contributing to disease pathogenesis has lagged behind identification of associated loci, thus...
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