Article
Candidate gene prioritization by network analysis of differential expression using machine learning approaches.
BMC bioinformatics - 14 Sept 2010
Nitsch Daniela, Gonçalves Joana P, Ojeda Fabian, de Moor Bart, Moreau Yves
Abstract excerpt
BACKGROUND: Discovering novel disease genes is still challenging for diseases for which no prior knowledge--such as known disease genes or disease-related pathways--is available. Performing genetic studies frequently results in large lists of candidate genes of which only few can be followed up for further investigation. We have recently developed a computational method for constitutional genetic disorders that...
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