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Article

Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes.

American journal of human genetics - 1 Jun 2006

Franke Lude, van Bakel Harm, Fokkens Like, de Jong Edwin D, Egmont-Petersen Michael, Wijmenga Cisca

Abstract excerpt

Most common genetic disorders have a complex inheritance and may result from variants in many genes, each contributing only weak effects to the disease. Pinpointing these disease genes within the myriad of susceptibility loci identified in linkage studies is difficult because these loci may contain hundreds of genes. However, in any disorder, most of the disease genes will be involved in only a few different...

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Identifiers

PMID: 16685651
DOI: 10.1086/504300
PMCID: PMC1474084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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