Article
The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy.
Biochemical and biophysical research communications - 3 Aug 2012
Li Xiaochuan Edward, Suphamungmee Worawit, Janco Miro, Geeves Michael A, Marston Steven B, Fischer Stefan, Lehman William
Abstract excerpt
Point mutations targeting muscle thin filament proteins are the cause of a number of cardiomyopathies. In many cases, biological effects of the mutations are well-documented, whereas their structural and mechanical impact on filament assembly and regulatory function is lacking. In order to elucidate molecular defects leading to cardiac dysfunction, we have examined the structural mechanics of two tropomyosin...
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