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Article

Fungal NOX is an essential factor for induction of TG2 in human hepatocytes.

Medical mycology - 1 Jul 2020

Huang Yao, Fujii Keisuke, Chen Xinyue, Iwatani Shun, Chibana Hiroji, Kojima Soichi, Kajiwara Susumu

Abstract excerpt

NADPH oxidases (Nox) generate reactive oxygen species (ROS) such as superoxide anion radical (O2-) and hydrogen peroxide (H2O2). The pathogenic fungi Candida albicans and Candida glabrata enhance cellular transglutaminase 2 (TG2) activity levels in co-cultured human hepatic cells in a ROS-mediated manner. Deletion of NOX1 (CgNOX1) in C. glabrata blocks the ability of C. glabrata to induce TG2 activity. Here, we...

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PMID: 31642483
DOI: 10.1093/mmy/myz105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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