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Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence

27 Jul 2023

Abstract excerpt

Metabolic flexibility enables fungi to invade challenging host environments. In Candida albicans, a common cause of life-threatening infections in humans, an important contributor to flexibility is alternative oxidase (Aox) activity. Dramatic induction of this activity occurs under respiratory-stress conditions, which impair the classical electron transport chain (ETC). Here, we show that deletion of the...

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Share to Antifungal resistance and susceptibility
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PMID: 37500616
DOI: 10.1038/s41467-023-40209-w

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