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Article

Thioredoxin regulates multiple hydrogen peroxide-induced signaling pathways in Candida albicans.

Molecular and cellular biology - 1 Oct 2010

da Silva Dantas Alessandra, Patterson Miranda J, Smith Deborah A, Maccallum Donna M, Erwig Lars P, Morgan Brian A, Quinn Janet

Abstract excerpt

The ability of the major systemic fungal pathogen of humans, Candida albicans, to sense and respond to reactive oxygen species (ROS), such as H(2)O(2) generated by the host immune system, is required for survival in the host. However, the intracellular signaling mechanisms underlying such responses are poorly understood. Here, we show that thioredoxin (Trx1), in addition to its antioxidant activity, plays a...

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Identifiers

PMID: 20679492
DOI: 10.1128/MCB.00313-10
PMCID: PMC2950526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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