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Article

Regulation of <i>Candida glabrata</i> oxidative stress resistance is adapted to host environment

13 Dec 2010

Abstract excerpt

The human fungal pathogen Candida glabrata is related to Saccharomyces cerevisiae but has developed high resistance against reactive oxygen species. We find that induction of conserved genes encoding antioxidant functions is dependent on the transcription factors CgYap1 and CgSkn7 which cooperate for promoter recognition. Superoxide stress resistance of C. glabrata is provided by superoxide dismutase CgSod1,...

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PMID: 21156173
DOI: 10.1016/j.febslet.2010.12.006

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