Article
Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects.
Developmental biology - 15 Aug 2010
Lakhwani Sita, García-Sanz Patricia, Vallejo Mario
Abstract excerpt
Neural tube closure defects are among the most frequent congenital malformations in humans. Supplemental maternal intake of folic acid before and during pregnancy reduces their incidence significantly, but the mechanism underlying this preventive effect is unknown. As a number of genes that cause neural tube closure defects encode transcriptional regulators in mice, one possibility is that folic acid could induce...
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