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Article

ICOSLG-mediated regulatory T cell expansion and IL-10 production promote progression of glioblastoma

18 Oct 2019

Abstract excerpt

BACKGROUND: Targeting immune checkpoint proteins has recently gained substantial attention due to the dramatic success of this strategy in clinical trials for some cancers. Inducible T-cell co-stimulator ligand (ICOSLG) is a member of the B7 family of immune regulatory ligands, expression of which in cancer is implicated in disease progression due to regulation of antitumor adaptive immunity. Although aberrant...

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PMID: 31634400
DOI: 10.1093/neuonc/noz204

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