FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15.

Abstract excerpt

Gliomas comprise a group of common primary brain tumors with a high degree of malignancy and a poor prognosis. There are currently no targeted therapeutics for glioma in clinical practice. The present study revealed a novel crosstalk circuitry mechanism that contributes to the overexpression of Friend leukemia virus integration 1 (FLI1) in glioma. FLI1, a member of the ETS transcription factor family, was...

Topics

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• Brain Neoplasms
• Cytokines
• Feedback, Physiological
• Glioma
• Interferons