Article
Infection-induced modulation of m1 and m2 phenotypes in circulating monocytes: role in immune monitoring and early prognosis of sepsis.
Shock (Augusta, Ga.) - 1 Nov 2004
Mehta Ashish, Brewington Ryan, Chatterji Manjil, Zoubine Mikhail, Kinasewitz Gary T, Peer Glenn T, Chang Alvin C K, Taylor Fletcher B, Shnyra Alex
Abstract excerpt
To monitor and better understand the immunoinflammatory sequelae in sepsis and septic shock, systemic and monocyte-related cytokine responses were evaluated in baboons with experimental peritonitis induced by an E. coli-laden fibrin clot. Despite similar bacterial inocula, considerable interindividual variability in clinical manifestation and outcome of infection was observed. Because monocytes and macrophages...
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